个人概况
张朋朋:男,博士,副教授,硕士研究生导师。
教育经历
2009-2015 华中农业大学、普渡大学 动物遗传育种与繁殖专业 联合培养博士
2005-2009 华中农业大学 动物科学专业 学士
工作经历
2015年至今 信阳师范学院 bevictor伟德 讲师
研究领域
1.发育生物学
2.动物遗传育种
工作介绍
1. 骨骼肌生长发育
在动物机体组成中,肌肉占动物体重的 40%以上,是动物主要的运动和代谢器官。骨骼肌的生长发育和再生主要依赖于骨骼肌干细胞(卫星细胞)的增殖和分化。常见的肌肉生长发育异常包括:肌肉营养不良、肌肉减少症、肌肉萎缩症、肌肉恶病质等,我们致力研究调控骨骼肌卫星细胞行为的编码基因和非编码基因,该研究将有助于提高动物生产性能及人类的生活质量。
2. 动物脂肪沉积
脂肪组织是机体能量的主要储存场所,体内过多的白色脂肪沉积会引发肥胖以及糖尿病,心脏病等疾病的发生。与白色脂肪不同的是,米色脂肪与棕色脂肪以产热的形式消耗大量能量,可以降低白色脂肪的沉积,提高米色脂肪与棕色脂肪的沉积成为解决肥胖相关疾病的重要途径。我们关注动物脂肪沉积的调控途径,相关研究将为解决肥胖问题提供理论依据。
主持科研项目
1.河南省重大公益专项,201300111200,河南省地方肉牛种质创新,2020/09-2022/08,子课题主持人
2. 国家自然科学基金青年项目,31601167,mTOR对米色脂肪棕色化和白色脂肪沉积的影响及差异性调控机制研究,2017/01-2019/12,主持
3. 河南省科技攻关计划项目,172102310547,抑制mTOR信号通路抵抗肥胖的效果和作用机制研究,2017/01-2018/12,主持
4. 河南省高等学校重点科研项目计划,17A230008,Tmem8c在猪骨骼肌卫星细胞增殖和分化中的作用及相关调控通路研究,2016/01-2018/06,主持
5. 河南省高等学校重点科研项目计划,21A230017,基于RPA和CRISPR-Cas12a的非洲猪瘟病毒高灵敏度快速检测,2021/01-2022/12,主持
6. 国家自然科学基金面上项目,31972537,RNA结合蛋白hnRNPK与miRNAs互作调控猪骨骼肌卫星细胞分化与骨骼肌发育的分子机理,2019/01-2022/12,参与
发表论文
1. Zhang, P.-p., Q. Han, M.-x. Sheng, C.-y. Du, Y.-l. Wang, X.-f. Cheng, H.-x. Xu, C.-c. Li and Y.-j. Xu (2021). Identification of Circular RNA Expression Profiles in White Adipocytes and Their Roles in Adipogenesis.Frontiers in Physiology 2021,12(1360).
2. Zhang P, Chao Z, Zhang R, Ding R, Wang Y, Wu W, Han Q, Li C, Xu H, Wang L: Circular RNA Regulation of Myogenesis. Cells 2019, 8(8).
3. Xu Yongjie, Wu Wei, Han Qiu, Wang Yaling, Li Cencen, Zhang Pengpeng*, Xu Haixia*: Post-translational modification control of RNA-binding protein hnRNPK function. Open Biology 2019, 9(3):180239. (共同通讯作者)
4. Xu Yongjie, Wu Wei, Han Qiu, Wang Yaling, Li Cencen, Zhang Pengpeng*, Xu Haixia*: New Insights into the Interplay between Non-Coding RNAs and RNA-Binding Protein HnRNPK in Regulating Cellular Functions. Cells 2019, 8(1).(共同通讯作者)
5. Zhang Pengpeng, Xu Haixia, Li Rui, Wu Wei, Chao Zhe, Li Cencen, Xia Wei, Wang Lei, Yang Jinzeng, Xu Yongjie: Assessment of myoblast circular RNA dynamics and its correlation with miRNA during myogenic differentiation. International Journal of Biochemistry & Cell Biology 2018, 99:211-218.
6. Xu Yongjie, Li Rui, Zhang Kaili, Wu Wei, Wang Suying, Zhang Pengpeng*, Xu Haixia*: The multifunctional RNA-binding protein hnRNPK is critical for the proliferation and differentiation of myoblasts. BMB Reports 2018, 51(7):350-355.(共同通讯作者)
7. Shan Tizhong, Zhang Pengpeng, Jiang Qinyang, Xiong Yan, Wang Yizhen, Kuang Shihuan: Adipocyte-specific deletion of mTOR inhibits adipose tissue development and causes insulin resistance in mice. Diabetologia 2016, 59(9):1995-2004.(并列第一作者)
8. Shan T, Xiong Y, Zhang P, Li Z, Jiang Q, Bi P, Yue F, Yang G, Wang Y, Liu X: Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3. Nature Communications 2016, 7
9. Zhang Pengpeng, Liang Xinrong, Shan Tizhong, Jiang Qinyang, Deng Changyan, Zheng Rong, Kuang Shihuan: mTOR is necessary for proper satellite cell activity and skeletal muscle regeneration. Biochemical and Biophysical Research Communications 2015, 463(1-2):102-108.
10. Shan Tizhong, Zhang Pengpeng, Bi Pengpeng, Kuang Shihuan: Lkb1 Deletion Promotes Ectopic Lipid Accumulation in Muscle Progenitor Cells and Mature Muscles. Journal of Cellular Physiology 2015, 230(5):1033-1041.(并列第一作者)
11. Zhang Pengpeng, Shan Tizhong, Liang Xinrong, Deng Changyan, Kuang Shihuan: Mammalian target of rapamycin is essential for cardiomyocyte survival and heart development in mice. Biochemical and Biophysical Research Communications 2014, 452(1):53-59.
12. Liu W, Shan T, Yang X, Liang S, Zhang P, Liu Y, Liu X, Kuang S: A heterogeneous lineage origin underlies the phenotypic and molecular differences of white and beige adipocytes. Journal of Cell Science 2013, 126(16):3527-3532.
13. Shan T, Zhang P, Liang X, Bi P, Yue F, Kuang S: Lkb1 is indispensable for skeletal muscle development, regeneration, and satellite cell homeostasis. Stem Cells 2014, 32(11):2893-2907.
14. Shan T, Zhang P, Xiong Y, Wang Y, Kuang S: Lkb1 deletion upregulates Pax7 expression through activating Notch signaling pathway in myoblasts. The International Journal of Biochemistry & Cell Biology 2016, 76:31-38.
联系方式:
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